Resource Type

Journal Article 4

Year

2021 2

2020 1

2017 1

Keywords

Psoraleae Fructus 2

idiosyncratic hepatotoxicity 2

Epimedii Folium 1

IL-1β 1

NLRP3 inflammasome 1

Polygonum multiflorum 1

bavachin 1

caspase-1 1

cis-transisomerization 1

idiosyncratic drug-induced liver injury 1

metabolomics 1

stilbene 1

traditional Chinese medicine incompatibility 1

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Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum

Chunyu Li, Ming Niu, Zhaofang Bai, Congen Zhang, Yanling Zhao, Ruiyu Li, Can Tu, Huifang Li, Jing Jing, Yakun Meng, Zhijie Ma, Wuwen Feng, Jinfa Tang, Yun Zhu, Jinjie Li, Xiaoya Shang, Zhengsheng Zou, Xiaohe Xiao, Jiabo Wang

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 253-265 doi: 10.1007/s11684-017-0508-9

Abstract: typical medicinal herb, Polygonum multiflorum (Heshouwu in Chinese), that induces idiosyncratichepatotoxicity to the whole extract in LPS-treated rats.The mixture of EA extract with other separated fractions induced comparable idiosyncratic hepatotoxicityhepatotoxicity to EA extract in LPS-treated rats.All these results suggested that cis-SG was closely associated with the idiosyncratic hepatotoxicity

Keywords： Polygonum multiflorum     idiosyncratic hepatotoxicity     metabolomics     stilbene     cis-transisomerization    

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New incompatible pair of TCM: Epimedii Folium combined with Psoraleae Fructus induces idiosyncratic hepatotoxicity

Yuan Gao, Zhilei Wang, Jinfa Tang, Xiaoyi Liu, Wei Shi, Nan Qin, Xiaoyan Wang, Yu Pang, Ruisheng Li, Yaming Zhang, Jiabo Wang, Ming Niu, Zhaofang Bai, Xiaohe Xiao

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 68-80 doi: 10.1007/s11684-019-0690-z

Abstract: Zhuangguguanjiewan pills (ZGW), which contain EF and PF, could induce immune idiosyncratic liver injuryprocessed and released by activating the NLRP3 inflammasome, is a specific indicator of EF-induced immune idiosyncratichepatotoxicity.PF combination indicates traditional Chinese medicine incompatibility, considering that it induces idiosyncratichepatotoxicity under immunological stress conditions.

Keywords： Epimedii Folium     Psoraleae Fructus     idiosyncratic hepatotoxicity     traditional Chinese medicine incompatibility    

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Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb,

Chunyu Li, Ming Niu, Zhaofang Bai, Congen Zhang, Yanling Zhao, Ruiyu Li, Can Tu, Huifang Li, Jing Jing, Yakun Meng, Zhijie Ma, Wuwen Feng, Jinfa Tang, Yun Zhu, Jinjie Li, Xiaoya Shang, Zhengsheng Zou, Xiaohe Xiao, Jiabo Wang

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 330-332 doi: 10.1007/s11684-020-0819-0

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Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratichepatotoxicity

Nan Qin, Guang Xu, Yan Wang, Xiaoyan Zhan, Yuan Gao, Zhilei Wang, Shubin Fu, Wei Shi, Xiaorong Hou, Chunyu Wang, Ruisheng Li, Yan Liu, Jiabo Wang, Haiping Zhao, Xiaohe Xiao, Zhaofang Bai

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 594-607 doi: 10.1007/s11684-020-0809-2

Abstract: Our previous studies have demonstrated that PF could cause idiosyncratic drug-induced liver injury (IDILI), but the mechanism underlying its hepatotoxicity remains unclear.isolated from PF enhances the specific stimuli-induced activation of the NLRP3 inflammasome and leads to hepatotoxicityBavachin also potentially contributes to PF-induced idiosyncratic hepatotoxicity.

Keywords： Psoraleae Fructus     bavachin     idiosyncratic drug-induced liver injury     caspase-1     IL-1β     NLRP3 inflammasome    

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Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum

Chunyu Li, Ming Niu, Zhaofang Bai, Congen Zhang, Yanling Zhao, Ruiyu Li, Can Tu, Huifang Li, Jing Jing, Yakun Meng, Zhijie Ma, Wuwen Feng, Jinfa Tang, Yun Zhu, Jinjie Li, Xiaoya Shang, Zhengsheng Zou, Xiaohe Xiao, Jiabo Wang

Journal Article

New incompatible pair of TCM: Epimedii Folium combined with Psoraleae Fructus induces idiosyncratic hepatotoxicity

Yuan Gao, Zhilei Wang, Jinfa Tang, Xiaoyi Liu, Wei Shi, Nan Qin, Xiaoyan Wang, Yu Pang, Ruisheng Li, Yaming Zhang, Jiabo Wang, Ming Niu, Zhaofang Bai, Xiaohe Xiao

Journal Article

Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb,

Chunyu Li, Ming Niu, Zhaofang Bai, Congen Zhang, Yanling Zhao, Ruiyu Li, Can Tu, Huifang Li, Jing Jing, Yakun Meng, Zhijie Ma, Wuwen Feng, Jinfa Tang, Yun Zhu, Jinjie Li, Xiaoya Shang, Zhengsheng Zou, Xiaohe Xiao, Jiabo Wang

Journal Article

Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratichepatotoxicity

Nan Qin, Guang Xu, Yan Wang, Xiaoyan Zhan, Yuan Gao, Zhilei Wang, Shubin Fu, Wei Shi, Xiaorong Hou, Chunyu Wang, Ruisheng Li, Yan Liu, Jiabo Wang, Haiping Zhao, Xiaohe Xiao, Zhaofang Bai

Journal Article